Kleine levin syndrome diagnosis

Kleine levin syndrome diagnosis

Publication date Here : June Journal: MediSur. Keywords: Kleine-Levin syndromecase reportssíndrome de Kleine-Levininformes de Kleine levin syndrome diagnosis. Se presenta el caso de un paciente masculino, de 18 años de edad, evaluado en la consulta de trastornos del sueño, en Villa Clara, por haber sufrido en cinco ocasiones de hipersomnia, de siete a diez días de duración, separados por tres o cuatro meses. Fuera del cuadro clínico de hipersomnia el comportamiento es normal. El paciente cumple los criterios de la 3ra Clasificación Internacional de los Trastornos del sueño para el diagnóstico del síndrome de Kleine-Levin. Kleine-Levin syndrome is a rare disorder characterized by recurrent episodes of hypersomnia, appetite disturbance, cognitive dysfunction and uninhibited behavior. It is estimated to affect Kleine levin syndrome diagnosis to five per million people and is four times more common in males. We present the case of an year-old patient treated at the sleep disorders consultation in Villa Clara due to five episodes of hypersomnia lasting seven to ten Kleine levin syndrome diagnosis, separated by three or four months. During these Kleine levin syndrome diagnosis he was irritable, apathetic and anorexic. When not suffering from hypersomnia, his behavior is normal.

The pronounced Kleine levin syndrome diagnosis disorder symptomatology, starting at 15 years of age with major depression and a suicide attempt, had impeded the identification of KLS, which was not diagnosed until the age of Kleine levin syndrome diagnosis Bipolar disorder may obscure KLS, with each condition adversely affecting the course of the other, and consequently, the co-occurrence of KLS and bipolar disorder may be underestimated.

Additionally, mood stabilizers may be effective for KLS and bipolar disorder. Rosalina Pisco Costa et. Yamila Borrayo Segundo et. The Kleine-Levin Syndrome. Sleep Sleep Res. Amsterdam Orlosky MJ. The Kleine-Levin Syndrome: A review. Psychosomatics ; De Burgos R, Cañadillas F. Síndrome de Kleine-Levin: revisión a propósito de un caso. Kleine levin syndrome diagnosis

Kleine levin syndrome diagnosis

Journal: MediSur. Keywords: Kleine-Levin syndromecase reportssíndrome de Kleine-Levininformes de casos. Se presenta el Kleine levin syndrome diagnosis de un paciente masculino, de 18 años de edad, evaluado en la consulta de trastornos del sueño, en Villa Clara, por haber sufrido en cinco ocasiones de hipersomnia, de siete a diez Kleine levin syndrome diagnosis de duración, separados por tres o cuatro meses.

En el episodio agudo mostraban Kleine levin syndrome diagnosis al sueño y en vigilia destacaba bradipsiquia, inquietud motora y gran labilidad emocional, con tendencia al llanto y necesidad de la presencia de los familiares.

Presentaron una duracion aproximada de dias Kleine levin syndrome diagnosis periodicidad mensual, y se mostraron asintomaticos entre los episodios. Los tres pacientes fueron valorados por pediatras, diagnosticados y tratados de encefalitis autoinmune. Representative transaxial tomographic slices are shown. Qualitative assessment detected irregular cortical function in both hemispheres, with more marked hypoactivity in the anterior and orbitofrontal regions, and in the right article source temporal region.

The left hemisphere showed defects in the orbitofrontal, temporobasilar, and mesial Kleine levin syndrome diagnosis. Asymmetry is observed in the basal nuclei, with decreased activity on the right side; Kleine levin syndrome diagnosis cerebellum is unaffected. During the 2-year follow-up, the patient presented a further 3 episodes of similar characteristics. A SPECT study performed 2 years after symptom onset revealed normal uptake in the frontal area and persisting alterations in the temporal region Fig.

Irregular cortical function is observed in both hemispheres, with defects of higher intensity in the orbitofrontal and temporal regions and small, diffusely distributed irregularities in the remaining areas of both hemispheres; no alterations are observed in the basal nuclei or cerebellum.

[Kleine-Levin syndrome: differential diagnosis in recurrent encephalitic syndromes in adolescence].

Compared with the previous studies, Kleine levin syndrome diagnosis improvement is observed in the defects in the orbitofrontal and temporal regions, with normal uptake in the anterior frontal region. Kleine-Levin syndrome is a rare disease whose diagnosis is based on clinical symptoms. Link patient presented successive episodes of self-limited hypersomnia, with no significant findings in any of the complementary tests performed during admission.

Aetiology of Kleine-Levin Kleine levin syndrome diagnosis remains unknown and clinical symptoms suggest the possibility of a hypothalamic-pituitary dysfunction caused by such trigger factors as head trauma, aseptic meningoencephalitis, or Prader-Willi syndrome.

Psiquiatria

Onset during adolescence, symptom recurrence, and infections as frequent trigger factors suggest an autoimmune aetiology; furthermore, an association between Kleine-Levin syndrome and HLA-DR1 has been observed. Now approaching the end of her first term there, she has only had two slumbering spells - each lasting a couple of weeks - since she started and her fellow students and tutors have been very understanding.

She said: "I have to think about it a lot and be careful to make sure everyone at uni knows that I have this problem. By Tom Ball. Megan will often have to bed down during the day wherever she happens to find herself if she feels the onset of an episode Image: Kleine levin syndrome diagnosis Real Life Get the biggest daily news stories by email Subscribe We will use your email address only for sending you newsletters.

Please see our Privacy Notice for details of your data protection rights. Thank you for subscribing Kleine levin syndrome diagnosis have more newsletters Show me See our privacy Kleine levin syndrome diagnosis.

Diagnosis Kleine-Levin Syndrome and tablets on a wooden table. La foto "Diagnosis Kleine-Levin Syndrome and tablets. La imagen es disponible para descarga en calidad de alta resolución hasta x It is edited by Dr.

The Journal accepts works on basic as well Kleine levin syndrome diagnosis research on any field of neurology. The Impact Factor measures the average number of citations received in Kleine levin syndrome diagnosis particular year continue reading papers published in the journal during the two receding years.

Kleine levin syndrome diagnosis

CiteScore measures average citations received per document published. Read more. SRJ is a prestige metric based on the idea that not Kleine levin syndrome diagnosis citations are the same.

Hipertension efectos en el corazon

SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field. Kleine-Levin syndrome is an infrequent neuropsychiatric disorder that manifests with recurrent, self-limited episodes of hypersomnia, normally accompanied by behavioural alterations hypersexuality, irritability, and aggressiveness and such cognitive alterations as confusion and hallucinations.

It presents in the second decade of life, with a higher incidence in young men Episodes last from Kleine levin syndrome diagnosis to 2 weeks, with complete remission read article symptoms.

Episodes may Kleine levin syndrome diagnosis several times per year, separated by asymptomatic periods.

We present the case of Kleine levin syndrome diagnosis year-old patient who, after symptoms of increased bowel activity, nausea, and low-grade fever, began to present a marked increase in somnolence, sleeping up to 20 hours per day; he was admitted to the internal medicine department. The CSF study showed a mildly elevated protein level. Considering a possible emotional origin, the Kleine levin syndrome diagnosis department assessed the patient on 3 occasions, with no abnormal findings and no dysfunction in the school or family setting.

Since the patient did not meet criteria for narcolepsy or idiopathic hypersomnia, and considering the history of gastrointestinal involvement and high CSF protein level, he was discharged with an initial diagnosis of post-infectious encephalitis, not ruling out other secondary origins Kleine levin syndrome diagnosis the symptoms.

Several days later, he was admitted to the neurology department due to more info hours of daytime sleep up to 20 hours per day.

Considering his tendency to sleep, hyperphagia, and behavioural alterations during wakefulness, and the presence of a gastrointestinal infection as the trigger factor for the symptoms, he was diagnosed with recurrent encephalitis. A brain perfusion SPECT scan revealed a cortical activity pattern not corresponding with the patient's age; the alterations observed were Kleine levin syndrome diagnosis with clinical suspicion of Kleine-Levin syndrome Fig.

Representative transaxial tomographic slices are shown. Qualitative assessment detected irregular Kleine levin syndrome diagnosis function in both hemispheres, with more marked hypoactivity in the anterior and orbitofrontal regions, and in the right mesial temporal region.

Embarazo de seis meses peso del bebe

The left hemisphere showed defects in the orbitofrontal, temporobasilar, and mesial Kleine levin syndrome diagnosis. Asymmetry Kleine levin syndrome diagnosis observed in the basal nuclei, with decreased activity on the right side; the cerebellum is unaffected. During the 2-year follow-up, the patient presented a further 3 episodes of similar characteristics.

Kleine levin syndrome diagnosis

A SPECT study performed 2 years after Kleine levin syndrome diagnosis onset revealed normal uptake in the frontal area and persisting alterations in the temporal region Fig.

Irregular cortical function is observed in both hemispheres, with defects of higher intensity in the orbitofrontal and temporal regions and small, diffusely distributed irregularities in the remaining areas of both hemispheres; no alterations are observed in the basal nuclei or cerebellum.

Compared with the previous studies, an improvement is observed in the defects in the orbitofrontal and temporal regions, with normal uptake Kleine levin syndrome diagnosis the anterior frontal region. Kleine-Levin syndrome is a rare disease whose diagnosis Kleine levin syndrome diagnosis based on clinical symptoms. Our patient presented Kleine levin syndrome diagnosis episodes of self-limited hypersomnia, with no significant findings in any of the complementary tests performed during admission.

Aetiology of Kleine-Levin syndrome remains unknown and clinical symptoms suggest the possibility of a hypothalamic-pituitary dysfunction caused by such trigger factors as head trauma, aseptic meningoencephalitis, or Prader-Willi syndrome.

Onset during adolescence, symptom recurrence, and infections as frequent trigger factors suggest an autoimmune aetiology; just click for source, an association between Kleine-Levin syndrome and HLA-DR1 has been observed. Differential diagnosis should include recurrent major depression, bipolar depression, and recurrent neurotic or organic hypersomnias, which are mainly caused by intraventricular tumours in the third or fourth ventricle.

Es normal tener flujo en el embarazo color blanco lechoso

Kleine levin syndrome diagnosis To rule out a personality disorder as the origin of the symptoms, it is essential to perform a psychological study during the clinical episode and continue reading asymptomatic period.

No psychiatric disorder was observed in our patient. Functional imaging has been Kleine levin syndrome diagnosis to be useful for studying the pathophysiology of the condition. During the Kleine levin syndrome diagnosis phase, SPECT typically reveal hypoperfusion in the uni- or bilateral temporal region, frontotemporal region, and basal ganglia.

In our case, SPECT revealed hypoperfusion in the right basal ganglia, both temporal regions, and the right Kleine levin syndrome diagnosis region. In interictal periods, results from the studies performed suggest that SPECT findings usually normalise, but temporal alterations persist even after clinical alterations have disappeared.

Findings from the second SPECT study were pathological, although the patient presented no symptoms; this is consistent with the results reported by Gabrieli et al. We conclude that brain perfusion Kleine levin syndrome diagnosis should be considered during episodes of recurrent hypersomnia in adolescents to rule out a possible associated Kleine-Levin syndrome.

ISSN: Previous article Next article. Issue 9. Pages November - December Lee este artículo en Español. Letter to the Editor. Download PDF. Ramírez Ocaña. Corresponding author. This item has received. Under a Creative Commons license. Article information. Considering a possible emotional origin, the psychiatry department assessed the patient on 3 occasions, with no abnormal findings and no dysfunction in the school or family setting.

Asymmetry is Kleine levin syndrome diagnosis in the basal nuclei, with decreased activity Kleine levin syndrome diagnosis the right side; the cerebellum is unaffected.

Figure 1. Compared with the previous studies, an improvement is observed in the defects in click the following article orbitofrontal and temporal regions, with normal uptake in the anterior frontal region.

Figure 2. Pedrós Roselló, B. Hoyo Rodrigo, E. A propósito de dos casos. Psiq Biol, 18Kleine levin syndrome diagnosis. Huang, C. Guilleminault, P. Kao, F. Sleep, 28pp. Annu Rev Psychol, 49pp. Rev Neurol, 36pp. Arias, J. Crespo-Iglesias, J. Pérez, I. Requena-Caballero, A. Sesar-Ignacio, M. Rev Neurol, 35pp. Vigren, M. Engström, A. Neurology, 5pp. Sociedad Española de Neurología. Subscribe to our newsletter. Instructions for authors Submit an article Ethics in publishing.

Article options.

Hasta que edad es buena la leche materna

Are you a health professional Kleine levin syndrome diagnosis to prescribe or dispense drugs? Política de cookies Cookies policy Política de cookies. Si continua navegando, consideramos que acepta su uso. Kleine levin syndrome diagnosis improve our services and products, we use "cookies" own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior.

Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Se continuar a navegar, consideramos que aceita o seu uso.